The COGA investigators assessed the participants’ response to alcohol using the SRE questionnaire. SRE scores can be used either categorically or quantitatively. For categorical analyses, a certain score on the SRE (e.g., the bottom third of the scores) is designated as a threshold, and people scoring below this value are classified as having a low response to alcohol. For quantitative measurements, the scores of all participants are considered and ordered along a continuum from lowest score (i.e., lowest response to alcohol) to highest score (i.e., highest response).