Chunk #17 — Materials and methods — Genotyping and CNV analysis — Gene set analyses — Statistical approaches

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De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

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The impact of biases relating to gene-set analyses of CNVs have been discussed elsewhere.19 To overcome those biases, we fitted the following logistic regression models to the combined set of case and control (or control de novo) CNVs and compared the change in deviance between (1) and (2). logit (pr(case))=CNV size + Total number of genes hit outside the gene set + number of genes hit in the gene set.logit (pr(case))=CNV size + Total number of genes hit outside the gene set.