Chunk #28 — 3. Results — 3.4 Association of Suicide and the Use of Smoking Cessation Medications — 3.4.2. Epidemiological/Clinical Data — 3.4.2.2. Nicotine partial agonists
Among the 2183 smokers exposed to varenicline in published trials, several AEs were more common with varenicline than placebo but suicide and depression were not cited as common AEs (Cahill et al. 2007; Nides et al. 2006; Keating & Siddiqui 2006; Fagerstrom & Hughes 2007). The two studies that reported on post-cessation mood reported varenicline improved mood compared to placebo (Nides et al. 2006; Jorenby et al. 2006). One trial reported a suicide in the placebo group (Oncken et al. 2006). Another trial reported a suicide in the varenicline group in a participant with a past history of depression (Tonstad et al. 2006). A non-RCT found that smokers with a past or current mental disorder did not have greater psychiatric AEs than smokers without this history (Stapleton et al. 2008).
