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Chunk #5 — EPIDEMIOLOGY OF OPIOID USE AND DEPENDENCE

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Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence.
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Substance use disorders are complex conditions that are present in varying degrees between individuals [20]. A person that is diagnosed with substance dependence often exhibits a set of specific cognitive, behavioural, and psychological symptoms such as an increase in dosage, duration of use, and efforts to obtain substances [20]. Opioid dependence is also characterized by tolerance and compulsive use despite harmful consequences that eventually lead to severe withdrawal symptoms and life-threatening complications [21].