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Chunk #6 — Introduction

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Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.
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schizophrenia-associated loci and 17 putative endophenotypes to address these questions: Are any of the 128 PGC schizophrenia-associated single nucleotide polymorphisms (SNPs) also associated with any of our 17 endophenotypes, especially those endophenotypes that show robust phenotypic associations with schizophrenia?Is an aggregate index of schizophrenia genetic liability (obtained by summing risk alleles, weighted by strength of association from the PGC findings) associated with any of these endophenotypes?Are there rare variants within the 108 PGC-identified loci that have reliable associations with any of these endophenotypes?