were found to be fourfold more common in individuals with autism than schizophrenia when they evaluated evolutionarily-constrained genes. This difference is critical for clinical genetics, genetic counseling, and possibly treatment. It also could be relevant for disentangling evolutionary processes underlying different psychiatric disorders, consistent with stronger natural selection on autism than schizophrenia. Finally, it would impact study design (if, for example, rare variants contribute little to OCD heritability).
