Similar to prior studies with younger adults (Slutske et al., 2019a, Slutske et al., 2019b), in the full national sample, the effect of first-degree relatives and high FH density on high-risk drinking strengthened as alcohol availability increased. Post hoc analyses (described below) showed this did not vary systematically by age, although our results suggest there may be different combinations of risk factors that are salient for certain population subgroups. Specifically, the interaction of FH and alcohol availability in relation to high-risk drinking was replicated in the subsample of women, and a similar pattern emerged for alcohol dependence among men and among Black drinkers. The finding for Black drinkers aligns with earlier studies showing neighborhoods have stronger effects for Blacks than Whites on alcohol outcomes, but our results do not align with similar prior findings for Hispanics (Karriker-Jaffe et al., 2012, Jones-Webb et al., 1997, Glass et al., 2017, Zemore et al., 2016). More proximal social factors may have a greater relative importance for dependence among Hispanic individuals than area-level factors. In fact, other studies have suggested that FH and US
