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Chunk #16 — Results — Results from the whole genome linkage scan — Genomewide significant linkage (LOD≥3.3) — Candidate genes

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Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP.
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We looked at the region of the peak with a LOD score of ≥2.0 (61–108 cM; 38–95 Mbp). Out of the 346 genes in this region we identified four candidate genes: corticotropin releasing hormone-binding protein (CRH-BP, MIM 122559) at 90 cM, homer homolog 1 (HOMER 1, MIM 604798) at 94 cM, cocaine-and amphetamine-regulated transcript (CART, MIM 602606) at 83 cM and serotonin receptor 1A (HTR1A, MIM 109760) at 77 cM. There were 20 genes located at the apex of the alpha and beta linkage peaks with LOD scores of 3.5 (90–93 cM, 75.7–77.6 Mbp). Of these, only CRH-BP could be considered a logical candidate gene for EEG and arousal-related behaviors.