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Chunk #17 — Discussion

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Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.
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The power to detect an effect size of 0.46 cm per allele with adult height was 60% at level p<0.05 using MAF = 0.31 (average MAF among the 48 SNPs) and an additive genetic model. This contributes to the fact that almost half of the signals were not replicated in our study since the known height variants tested typically have a 0.2–0.6 cm per allele effect size.