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Chunk #30 — 4. Discussion

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Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
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have notable effects on AD. Overall, although we did not observe direct effects of single markers in the GAD genes on the risk to develop AD, they may have impact via their influences on initial sensitivity to ethanol and the onset age of developing AD.