Chunk #34 — Results — Developmental shift in the subcellular localization of GIRK subunits — Extrasynaptic GIRK-containing channels

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Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.

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particles examined for GIRK1, GIRK2 and GIRK3, respectively). Along the plasma membrane, most immunoparticles (84% of GIRK1, 86% of GIRK2 and 69% of GIRK3) were found in postsynaptic compartments, and the remainder (16% of GIRK1, 14% of GIRK2 and 31% of GIRK3) in axon terminals (Figs 5H and I, and 6H). Immunoparticles for GIRK3 were also found at mossy fibre terminals in the CA3 region of the hippocampus (Fig. 6G).