regulation of ryanodine receptors (Jalilian et al., 2008), 14-3-3 proteins (Suginta et al., 2001) and A-kinase anchoring proteins (Shanks et al., 2002). The Clic gene family is represented in mammals, flies and worms by six (Clic1–Clic6), one (Clic) and two (exc-4 and exl-1) loci, respectively. Our studies establish that members of the Clic gene family are key modulators of ethanol behavior in flies, worms and mice.
