The genotype effects of the Oprm1 A112G substitution were then examined in males and females separately. As shown in Fig. 2, male A/A mice showed significantly higher [3H]DAMGO binding than G/G mice in the cingulate and insular cortices, NAc core and shell, thalamus, hypothalamus, amygdala, PAG, substantial nigra, and VTA. In contrast, female A/A mice displayed significantly higher [3H]DAMGO binding than G/G mice only in the thalamus, amygdale, PAG, and SuG. Therefore, A112G has more pronounced effects on MOPR levels in males than in females.
