Chunk #0 — INTRODUCTION

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

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Cigarette smoking is a major public health problem and the single largest cause of preventable death in the world, contributing to over 5 million deaths a year [1]. In the United States, smoking causes approximately 443,000 deaths each year including an estimated 82% of lung cancer deaths [2].