There was no significant difference in NMR between the daily and the non-daily smokers. However, there was a trend toward daily smokers metabolizing more slowly than non-daily smokers (12 versus .18, p=.07). In the multivariate analyses, NMR was inversely related to CPD, such that faster metabolizers smoked fewer CPD (see Table 2). That is, every 1-point increase in NMR was associated with a decrease of 3.61 (1.92) cigarettes per day, after adjusting for gender and duration of smoking.