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Chunk #36 — Results — Group comparison – P1 amplitude and latency

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Increased intra-participant variability in children with autistic spectrum disorders: evidence from single-trial analysis of evoked EEG.
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Although not the main area of interest in this article, P1 latency and amplitude were compared between groups as this is the first study to report P1 amplitude calculated from single-trials rather than the average ERP in individuals with ASD. It has been suggested that individuals with ASD may show hyper-sensitivity in posterior cortical areas associated with early visual perception (Mottron et al., 2006). As such, significantly greater P1 amplitude could be predicted3. Given that individuals with ASD show increased latency jitter compared to TD participants (see above), the amplitude of the ERP could be artificially reduced in this population, masking any such effect. By contrast, computing P1 from the single-trials creates a variable that is immune to the effects of latency jitter. However, there was no group difference in P1 amplitude from any data source when calculated from either the ERP peak or the median of single-trials (all t < 1. all p > 0.4). Figures 3D,E illustrate P1 amplitude when calculated as the peak of the ERP (Figure 3D) and the median amplitude of the single-trial peaks (Figure