As shown in Table 2, only the AUDIT-P PRS was significantly associated with DSM-IV alcohol dependence (R2 = 0.68%, p = 4.55e-9) and DSM-5 AUD symptom count (R2 = 0.67%, p = 1.01e-10). For individuals in the top quartile of AUDIT-P PRS risk, the odds of being diagnosed with alcohol dependence was 1.74 (95% confidence intervals (C.I.) = 1.47–2.07) compared to those in the lowest quartile, while being in the top AUDIT-C PRS quartile was associated with an odds ratio (OR) of 1.30 (95% C.I. = 1.10 −1.54) compared to those in the lowest quartile (Figure 1). Comparison of the OR and their 95% C.I. suggest that for AUDIT-C, those in the 4th quartile are at significantly elevated likelihood of AUD compared to those in lowest quartile, though there were overlapping 95% C.I. between the 2nd, 3rd, and 4th quartiles. In contrast, for AUDIT-P, likelihood of AUD escalates at the mid-point, with those in the both the 3rd and 4th quartiles being at significantly greater risk of AUD than those in the lowest quartile of AUDIT-P PRS.
