a strikingly large fraction of variance (up to 31%) in NMR in the current sample, suggesting that they tag both known and unidentified functional variants. The population-attributable effect of the detected independent variants is thus far greater than that of the four functional variants frequently genotyped in Caucasians (CYP2A6*2, *4, *9, and *12). Further, we enclose evidence for plausible epigenetic mechanisms on 19q13.2 influencing NMR.
