suggest recent review papers that cover GWAS of AD (Kimura and Higuchi, 2011; Treutlein and Rietschel, 2011). Notably, several GWAS have validated some candidate genes. For instance, the ADH1C gene, which has over 50 publications linking it to alcohol use/alcoholism/AD, has also been evidenced in two recent GWAS of AD (Kendler et al., 2011; Treutlein et al., 2009). Similarly, the muscarinic receptor (CHRM2) has been replicated in two GWAS (Dick et al., 2008; Kendler et al., 2011), and several other well replicated candidate genes (i.e., >10 studies), such as GABRA2 (Bierut et al., 2010), MAOA (Wang et al., 2011a), GRIN2B (Joslyn et al., 2010), and ANKK1 (Kendler et al., 2011) have emerged in recent GWAS.
