Text). We use this model in most analyses reported in the manuscript, except where otherwise noted (see Supplementary Fig. 2). We discuss the addition of surrogate variables (Supplementary Fig. 4G, H and Supplementary Text); the fit of the various models to the data is summarized in Supplementary Fig. 4I. Graphical display of the distribution of selected covariates by diagnosis are provided for the CommonMind Consortium (CMC) and Human Brain Cohort Collection (HBCC) data in Supplementary Fig. 5, which demonstrate that cases and controls show roughly the same ranges.