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Chunk #30 — Risk Factors for AUD from Neuropsychological, Neurophysiological, and Neuroimaging Studies — Disinhibition

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Neural circuitry associated with risk for alcohol use disorders.
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Additionally, youth with a family history of AUD display reduced EROs on go/no-go tasks predominantly at parietal-occipital and centro-parietal regions (Cohen et al. 1997; Kamarajan et al. 2005, 2006). Children of alcoholics tend to have reduced gamma band activity in parietal regions while processing the target stimulus during a visual oddball task (Padmanabhapillai et al. 2006). Similarly, high risk children from multiplex families have reduced delta and theta band EROs to the target stimulus during the same task (Rangaswamy et al. 2007). A significant reduction of delta and theta EROs has been postulated to underlie the decreased P3 amplitude often observed in the offspring of alcohol dependent individuals (Porjesz et al. 2005).