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Chunk #12 — Methods — DNA preparation and assessment of allelic frequencies

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Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples.
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To confirm the SNPs within the positive clusters from the current dataset, we sought convergence between data from these clustered nominally-positive SNPs and clustered nominally-positive SNPs, determined in the same way, from 1 M SNP genome wide association studies of the MNB samples (Drgon et al, submitted). To provide insights into some of the genes likely to harbor variants that contribute to individual differences in vulnerability to substance dependence, we sought candidate genes that were identified by overlapping clusters of positive SNPs from each of these samples.