Chunk #11 — Material and Methods — Operant self-administration paradigm — Operant apparatus

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Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats.

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Self-administration testing was conducted in standard operant conditioning chambers (Coulbourn Instruments, Allentown, PA). Details regarding the apparatus have been extensively described elsewhere (Richards et al., 2008; Steensland et al., 2007).