candidate, Iih4, was significantly correlated with LDL and TC levels in liver. In humans, this gene is also linked to hypercholesterolemia in OMIM and was previously associated with BMI in East Asians41. Due to complex correlation of phenotypes, it is difficult to assess whether this gene set is significant in aggregate and genes in the HMDP are typically expected to have strong effects. We could not perform enough random selections of genes to establish significance for this set. However, we consider the 26 individually significant genes to be fruitful targets for follow-up studies.
