To our knowledge, this is the first study that compares the prevalence of DSM-IV-TR Axis I disorders in MA-, heroin- and co-dependent males in China. MDs and M/HDs tended to be slightly younger and started using drug at an earlier age (Percentage of onset age of drug use before 25: 33.8% in MDs, 35.6% in M/HDs and 24.6% in HDs). MA might be more available to and fashionable among teenagers and young adults. Barati et al. [5] reported that for nearly half of MA users, the mean drug-abuse initiation age was <18 years old. In addition, Li et al. [30] reported being ≤25 years old was an independent factor associated with current MA use in a China-Myanmar border region. The percentage of married, remarried, or cohabiting users in our study (33.81–41.33%) was as low as, based on Grella et al. [20], who reported that 49% of their 578 participants were in one these categories, and on Salo et al. [43], who reported that 28% of their 189 participants were also.