Study limitations are primarily related to the small laboratory sample size, resulting in a limited range of FHD and diversity, and limited power to detect smaller effect sizes. Further, Maxdrinks was determined over the 35 day timeline follow‐back interval in the laboratory sample compared with the lifetime assessment in the COGA dataset. However, variability in timeframe and drinking pattern assessment is also present in the larger literature, 9 , 11 , 12 , 13 , 14 and the optimal timeframe and metrics for assessing drinking intensity likely varies with the question of interest; potentially serving as either a state or trait risk factor. In the laboratory sample, however, the groups each consumed alcohol over a similar timescale—approximately 3 days per week, and across the entire sample, this was typically the weekend (Figure S2). Thus, the primary difference was the intensity of each event. In that context, our survival analysis results appear to be reflective of recent drinking intensity. Consequently, further study will be required to assess the potential impact of acute and/or chronic tolerance on our alcohol self‐administration and subjective
