receptors. More specifically, OXT via signaling at OXTR-a(2A)AR heteroreceptor complex may act as an allosteric antagonist to reduce adrenergic signal transduction (Diaz-Cabiale et al., 2000). It is also likely that a(2A)ARs can also modulate OXTRs through reciprocal receptor-receptor interaction (Fuxe et al., 2012). Interestingly, OXTR-(2A)AR heterodimers have been located within hypothalamic and amygdala regions as well as the nucleus of the solitary tract (NTS), which is well situated to mediate both central and autonomic stress effects (Diaz-Cabiale et al., 2000, Fuxe et al., 2012) that may be involved in withdrawal-related symptoms and stress-related relapse.
