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Chunk #45 — Discussion

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Genome-wide association study of antisocial personality disorder.
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The results of this study need to be interpreted carefully. There are examples of how the genetic associations of ASPD may be or have been misused for prediction purposes or in courthouses.58, 59 The concept of heritability is sometimes misinterpreted. When ASPD is described as 50% heritable, it implicates that heritability explains 50% of the variance in that population in which the study was conducted in, and not that on the individual level an ASPD subject had inherited 50% of the disorder from their parents and 50% was due to the environmental influences. The findings of this study cannot be implemented for any prediction purposes, or brought into courthouses to be given any legal weight. Instead, this study serves well as a candidate variant reservoir for personality traits and disorders adding to the few candidate variants that have previously existed for ASPD. Important next steps would be to discover the causal factors tagged by the findings here and to elucidate the molecular functions involved with ASPD. In conclusion, our results showed a robust signal for several variants located beside LINC00951