Technological advances enable the development of different experimental approaches. A genetic susceptibility map, as put together in this review, contains scientific evidence from diverse approaches and can serve as a draft of the “parts list” to be updated periodically until complete.38 We hope such an enumeration will catalyze an array of specific targeted and nuanced scientific studies, as suggested by Sullivan et al.;38 e.g., calculating the heritability explained by the 47 genetic loci, replicating association signals currently inadequately supported, identifying causal variant(s) within each locus through expression data integration and functional characterization, selecting appropriate phenotypic measures of ND, elucidating biological mechanisms between the genotype and ND, exploring gene–gene and gene–environment interactions, understanding the part played by epigenetic modifications, developing and evaluating treatment prediction models, and so forth.
