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Chunk #62 — 7. Replication and Meta-Analysis — 7.2 Meta-Analysis of Multiple Analysis Results

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Chapter 11: Genome-wide association studies.
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perhaps examine a different underlying hypothesis than others in the meta-analysis, much like outlier analysis is used to identify unduly influential points. Just as with outliers, however, a study should only be excluded if there is an obvious reason to do so based on the parameters of the study – not simply because a statistic indicates that this study increases heterogeneity. Otherwise, agnostic statistical procedures designed to reduce meta-analysis heterogeneity will increase false discoveries.