Analyses of multipoint variance component LOD scores, for the “FIRST FIVE” SRE phenotype, revealed two loci that had a LOD score greater than 3.0 on chromosomes 6 (LOD= 3.86) and 9 (LOD= 4.5). Figure 1 presents the linkage peaks generated by these analyses across the genome. Three additional locations were identified with LOD scores above 2.0 on chromosomes 10 (LOD=2.7), 12 (LOD=2.43), and 17 (LOD=2.87) for the “FIRST FIVE” SRE phenotype that are seen in Figure 2. Table 2 presents the peak LOD scores, the closest marker location for the loci identified, empirical p values, and additionally gives information of other findings in the literature for substance-related phenotypes observed at or near those locations.
