Rather than apply the traditional seed-based functional connectivity approach where seeds, or clusters of voxels, are determined a priori based upon known task involvement, regions of interest (ROIs) relevant to retrieval and other processes, such as attention and working memory, were sampled throughout the entire brain. Other functional connectivity methods, such as voxelwise comparisons of the entire brain38, generate an unbiased, detailed profile of functional networks but encounter problems of multiple comparisons. The center of mass of twenty-six anatomical volumes delineated in standardized brain space50 was used to determine the coordinates of thirteen bilateral ROIs. The ROIs selected for this study depended on the defined masks in the atlas, resulting in restricted availability for some regions, such as retrosplenial cortex. Each ROI consisted of a 10 millimeter cube (a total of 125 voxels) assembled around the center of mass coordinate. If the constructed cubes encompassed voxels from surrounding regions, the cube was shifted in the x, y, or z coordinate directions to ensure the cube was comprised of voxels only belonging to the specified ROI. Finally, the hippocampus bilaterally was
