β is a cytokine expressed in brain that is capable of controlling microglial activation, this signaling pathway may have the potential to regulate alcohol consumption. MicroRNAs that targeted these hubs included miR-34a-5p, miR-17-5p, miR-181a-5p, miR-16-5p for Bcl2 in the AMY (except for miR-16-5p, these microRNAs are involved with immune response [66]), and miR-335-5p for Bcl2 in the PFC (identified in the time-point and cluster based pairings). In NAC, miR-34a-5p and miR-146a-5p are potentially important regulators of Erk1/2 and NF-kB signaling pathways (the time-point based pairings only), respectively.
