A number of studies have provided modest evidence for association of SNPs in the ADH4-ADH5 region with AD (Edenberg et al., 2006) (Kuo et al., 2008) (Kendler et al., 2011) (Luo et al., 2006b). A key issue to keep in mind is that there is a very strong LD block that extends across ADH4 and ADH5, so findings in ADH5 might relate to effects in ADH4, to regulatory effects on other genes, or to LD with rs1229984 in ADH1B. In a Korean GWAS, the initial evidence for association of 2 SNPs in ADH5 with AD disappeared when conditioned on ADH1B*2 (Park et al., 2013).
