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Chunk #27 — RESULTS — Virginia Adult Twin Study of Psychiatric and Substance Use Disorders

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Measures of current alcohol consumption and problems: two independent twin studies suggest a complex genetic architecture.
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In summary, the best-fitting model across both samples indicated that a single latent genetic factor cannot explain the genetic influences on all consumption and problem measures. Rather, several latent genetic factors are needed (Figs. 3 and 4). The first (A1) loads most heavily on the frequency items, but retains considerable influence across the other items. A second latent genetic factor (A2) loads more heavily on the heavier drinking items but again retains considerable influence on all items. Additional latent genetic factors are more specific to other consumption measures, with both samples showing some latent genetic influences specific to measures of alcohol problems (unshared with any of the measures of consumption).