Australia (N = 16,302 response rate 83%), a comprehensive psychiatric interview assessing the physical, psychological, and social manifestations of alcoholism and psychiatric disorders in adults [Bucholz et al., 1994, 1995; Hesselbrock et al., 1999] according to DSM-IV criteria [American-Psychiatric-Association, 1987]. Participants (N = 4,949) have subsequently provided a blood (or buccal/saliva in ~4% of cases) sample. Summary statistics characterizing the cohorts are provided in Table I supp. The “SSAGA” case–control sample in Wray et al. [2009] were unrelated individuals from the cohorts reported here. The 824 MZ twins used in the study of Wray et al. [2008] were also included in the present study. Study participants were middle-aged: mean = 32.3; SD = 13.6; range = 18–95 years; and were 60% female.
