The Poisson GLM for erroneous sequencing read counts with log link function is expressed in eq. (1), where Ns,b,l is the observed number of erroneous reads for strand s (forward or reverse) with alternative base b (three possible values other than the reference) at location l, λs,b,l represents the expected mean for Ns,b,l, cs,b,l is the vector of genomic sequence context covariates, and β is the vector of fitted coefficients. The sequencing depth for strand s at location l is treated as the offset.1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \log \left({\lambda}_{s,b,l}\right)= \log \left(E\left({N}_{s,b,l}\Big|{\boldsymbol{c}}_{s,b,l}\right)\right)= \log \left({d}_{s,l}\right)+{\boldsymbol{\beta}}^{\boldsymbol{\hbox{'}}}{\boldsymbol{c}}_{s,b,l} $$\end{document}logλs,b,l=logENs,b,l|cs,b,l=logds,l+β'cs,b,l
