Theoretically, these results raise questions about the need for detailed measures of the DSM-IV criteria for AD such as tolerance, dependence, narrowing of behavioral focus and use despite persistent problems. Some of these constructs are challenging to assess especially retrospectively. Our results suggest that considerably simpler consumption-like measures for the period of heaviest drinking can index the same genetic risk factors that predispose to the subtler construct of dependence as it is imperfectly assessed by structured clinical interview.
