given locus is attributable to adipose accumulation. When the overall contribution of these SNPs was assessed using the GBS, strong associations were evident for all anthropometric (Fig. 2A and B) and dual-energy X-ray absorptiometry (DEXA) measures of obesity (Fig. 2C–E). For example, when stratified into quintiles, those with the highest level of the GBS (Q5) weighed approximately 2.56 kg more than those with the lowest level of the GBS (Q1) (β = 0.87 kg per SD increase in score, P < 0.0001). Consistently, BMI was 0.97 kg/m2 higher (β = 0.32 kg/m2 per SD increase in the score, P < 0.0001), total adipose mass was 2.41 kg higher (β = 0.76 kg per SD increase in the score, P = 0.0001), abdominal adipose mass was 0.14 kg higher (β = 0.04 kg per SD increase in the score, P = 0.0004), and gynoid adipose mass was 0.19 kg higher (β = 0.06 kg per SD increase in the score, P = 0.0002) in the top versus bottom quintiles of the GBS.
