Chunk #27 — ONLINE METHODS — Imputation

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Genome-wide association study identifies five loci associated with lung function.

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Imputation of nongenotyped SNPs was undertaken with MACH36 or IMPUTE37 with preimputation filters and parameters as shown in Supplementary Table 1. SNPs were excluded if the imputation information, assessed using r2.hat (MACH) or .info (IMPUTE), was <0.3. In total, 2,705,257 autosomal SNPs were analyzed.