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Chunk #22 — RESULTS — Dendritic Spine Phenotypes

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Postnatal binge-like alcohol exposure decreases dendritic complexity while increasing the density of mature spines in mPFC Layer II/III pyramidal neurons.
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One-way ANOVA demonstrated significant differences in the spine phenotypes (Figure 6a) of both Order 2 (F (2, 14) = 8.175, p=.006) and Order 4 (F (2, 14) = 8.044, p=.006) dendritic spines. Turkey post hoc comparison revealed significant differences between the AE and SC animals in both the Order 2 (p=.005) and the Order 4 (p=.005) spines, wherein there was a significant increase in the density of mature spines compared to the percentage of immature spines (Figure 6b). Also, there was no difference between SC and SI in either Order 2 (p=.343) or Order 4 (p=.514).