Three cortical regions of interest (the left inferior parietal cortex and the right and left insula) were significantly thinner when all dependent groups were compared with control subjects (model 1) and when all dependent groups except alcohol were contrasted against control subjects (model 2). In addition, the left insula was significantly thinner in the alcohol-dependent group alone relative to control subjects (Tables 2 and 3, Figures 1 and 2).