studies have subsequently found modest evidence that SNPs in MPDZ were associated with risk for alcoholism but interestingly, not alcohol withdrawal seizures (Karpyak et al. 2009, 2011). The failure to demonstrate an association with withdrawal seizures in particular could reflect the imprecise nature of translation between species or could simply reflect poor power to detect such an association in humans, where many environmental and genetic factors also influence this trait. It is also possible that these relatively small studies showing an association between alcoholism and SNPs in MPDZ represent false positive findings (Munafo and Flint 2011).
