Furthermore, age at the time of first alcohol use predicts CUD (OR = .88, p = .04, 95% CI [.78, .99]) as well as mediates the association between TLI and CUD (z = 2.17, p = .03). Complementing this finding, age at the time of first cannabis use predicts AUD (OR = .89, p < .001, 95% CI [.83, .96]) and mediates the association between TLI and AUD (z = 2.27, p = .02). In effect, age at the time of first use of alcohol or cannabis is an indicator of nonspecific transmissible risk for both AUD and CUD.
