Chunk #17 — Results — Phenotypic buffering

Source

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

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Although the observed convergence provides insight into downstream genes, it is not clear whether the MPV or MCV phenotypes are eventually caused through these trans-genes, or whether these trans-eQTLs emerged as a result of changes to the volume of the platelets or the erythrocytes.