In the final adjusted model, several sociodemographic and substance use characteristics remained statistically significantly associated with perceived risk of regular cannabis use (Table 5). For instance, females had 1.74 times the odds (95% Confidence Interval (CI)=1.71–1.77) of reporting perceived great risk of regular cannabis use compared to men. The same pattern was observed for participants who reported Black (aOR=1.08, 95% CI=1.05–1.12), Hispanic (aOR=1.75, 95% CI=1.69–1.81) and Other race/ethnicities (aOR=1.54, 95% CI=1.47–1.61). Compared to individuals ages 12–17, participants ages 18–25 (aOR=0.66, 95% CI=0.64–0.69) and ages 26–49 (aOR=0.93, 95% CI=0.90–0.96) had lower odds of perceiving great risk of regular cannabis use, while participants age 50 and older had higher odds (aOR=1.37, 95% CI=1.31–1.42) of perceiving great risk of regular marijuana use. Participants with a high school education or greater had lower odds of reporting perceived great risk of regular use (aOR=0.75, 95% CI=0.72–0.77) compared to those without a high school diploma. Compared to those with a total family income of $0-$19,999, participants with an income of $20,000-$49,999 had an increased odds of great perceived risk (aOR=1.06, 95% CI=1.03–1.09), while participants with an