Chunk #26 — Results — Analysis of rare de novo CNVs in the Simons Simplex Collection (SSC) — Genotype-phenotype analyses of probands carrying any rare de novo CNV
In contrast, we found that male intellectual functioning was relatively more vulnerable to the effects of rare de novo CNVs. Again using a series of stepwise linear models we evaluated the relationship between intellectual functioning, sex, and the number of genes within rare de novo CNVs. For males, there was a significant relationship between IQ and number of genes (p=0.02), with the model predicting a decrease of 0.42 IQ points for each additional gene. In contrast, for females the estimated effect was ten-fold less and did not approach significance (Figure 3D).
