al., 2019b), and with evidence that individuals who are treated for AUD differ substantially from those with AUD who are not treated (Fein and Landman, 2005, Dawson, 1996, Dawson et al., 2006). The different results in abstinent and non-abstinent demonstrate that individuals with less severe AUD, who have lower PGSAUD and/or who have not yet progressed to severe AUD, were less likely to seek treatment and PGSAUD was a significant indicator for future remission, whereas those with severe AUD were more likely to seek treatment and treatment history became the significant indicator for future remission. The treatment rates of greater than 50% in COGA EA and AA samples in this study were higher than the 19.8% rate found among individuals with lifetime AUD in the U.S population (Venegas et al., 2021). This is likely due to the fact that AUD risk family ascertainment was based on recruitment of probands who were in treatment for alcohol dependence but may also reflect the fact that individuals with more severe AUD are more likely to perceive a need for treatment (Pinedo and Villatoro, 2020). Nonetheless, the strong association of treatment with remission provides evidence that treatment is effective even among individuals at highest
