In view of the critical need to systematically examine sex differences in genetically informed studies of AUD [55], sex differences previously observed in EEG measures in the analytic sample [56], and to correspond to methods presented in other genetic studies of development [57], sex specific models were utilized. Covariates in the model included family history of AUD, ancestral principal components (PC1-PC3), and a sex × PRS interaction term. Weights for individuals were adjusted to account for multiple observations on single individuals and co-presence of related individuals (e.g., siblings) in each of the local linear regression calculations.
