The purpose of this study was to test a GRSS comprising replicated genome-wide significant variants as well as additional variants with suggestive evidence catalogued from large-scale meta-analyses for association with BMI in 2,653 European-Americans and 973 African Americans from the Molecular Genetics of Schizophrenia control sample (MGS-C). Based on the expected BMI effect sizes of 0.05–0.3 kg/m2 per allele change in BMI, the MGS-C sample would have limited power to detect genome-wide significant variants for individual loci. However, the aggregate risk should be adequate if a sufficient proportion of the reported variants are real. Therefore, these analyses serve as a replication attempt of top variants catalogued from large-scale meta-analyses via a sum score approach.
